L Arginine Alpha Ketoglutarate

Arginine Alpha-Ketoglutarate provides far superior uptake and retention as compared with regular L-Arginine. The unique combination of ingredients in this product make it the strongest nitric oxide supplement on the market.

L-Arginineódilates blood vessels, normalize blood pressure, replicates the activity of nitroglycerine, and is needed to produce nitric oxide

L-arginine, along with a properly planned exercise program, assists in amending abnormalities occurring in blood vessels. Individuals with congestive heart failure often have blood vessels that fail to dilate in response to certain drugs, a sign that the inner blood vessel wall, or endothelium, is compromised.

A study reported in the American College of Cardiology concluded that treatment with L-arginine produced a fourfold increase in blood vessel dilation from 2.2-8.8% (Hambrecht et al. 2000). Regular forearm exercises increased the dilation response by the same amount, but the combination of L-arginine and exercise training resulted in an improvement from 2.9-12%. Doses of 5.6-12.6 grams of arginine increased blood flow to the extremities 29%; the distance walked on a treadmill in 6 minutes increased 8% (Rector et al. 1996).

Much of L-arginine's effectiveness comes by way of increasing nitric oxide, a blood vessel dilator and clot buster produced in endothelial cells by the enzyme nitric oxide synthase (Brunini et al. 2002). Nitric oxide counteracts the vasoconstriction and platelet-aggregating effects of the stress hormone adrenaline (epinephrine) and assists in maintaining vascular elasticity. Nitric oxide (the endothelial relaxing factor) is needed for expansion and contraction of the arterial system (Rohdewald 1999). L-arginine increases nitric oxide, but hypertension, hyperhomocysteinemia, diabetes, and smoking decrease it.

Because of arginine's vasodilating properties, it is frequently used as a treatment for angina pain and hypertension. Researchers at the University of Southern California ( Los Angeles ) speculate that a defect in nitric oxide production may be a possible mechanism of hypertensive disease (Campese et al. 1997). Some cardiologists, in fact, recommend L-arginine over nitroglycerine, since the two substances appear to replicate a similar vascular function: the ability to relax smooth muscles and dilate blood vessels.

L Arginine & Nitric Oxide Synthesis

Nitric oxide is a soluble free gas naturally produced in the body (from the amino acid arginine) by endothelial cells, macrophages, and specific neurons in the brain. Nitric oxide plays several key roles in the body, including:

  • Nitric oxide relaxes vascular smooth muscle, which causes vasodilation.
  • Nitric oxide reduces platelet aggreg r ation and adhesion.
  • Nitric oxide produced by macrophages is cytotoxic to certain microbes and tumor cells.

Nitric oxide has been identified as having a key role in blood pressure regulation. Nitric oxide lowers blood pressure by stimulating the release of calcium from vascular smooth muscle cells, thereby causing the blood vessels to relax and dilate. There is now evidence that nitric oxide deficiency can cause hypertension and may also be involved in the pathogenesis of atherosclerosis. Nitric oxide donors (such as nitroglycerine and arginine) lower blood pressure and increase cerebral blood flow in patients with acute ischemic stroke.

L Arginine Modulating Nitric Oxide

The best naturally occurring source of nitric oxide is the amino acid arginine. A study examined the use of L-arginine to prevent experimental ischemic stroke in rats. L-arginine was administered at the time of ischemia and at 6 and 24 hours later. The areas of neuronal necrosis were reduced by 99%, 96%, and 89%, respectively. The study also examined L-arginine in combination with a calcium antagonist (TMB-8) and found that the combination of TMB-8 and L-arginine is more effective in treating ischemic stroke by simultaneously reducing calcium-activated proteolysis and improving cerebral blood flow than using TMB-8 or L-arginine alone (Hong et al. 2000).

However, to avoid the potentially harmful free-radical damage that can result from excessive nitric oxide, one of the vitamin E fractions, gamma tocopherol, has been found to function as the best antioxidant for nitric oxide. Therefore, for best stroke, heart disease, and hypertension protection, consider arginine, 2700 mg 3 times per a day with plenty of B complex as cofactors and 400 IU of gamma tocopherol for optimal protection.

Precautions when supplementing with arginine:

  • Diabetics and borderline diabetics should use arginine with care because it may worsen diabetes.
  • Children, teenagers, and pregnant or lactating women should not use arginine (or growth hormone stimulators) except under the care of a knowledgeable physician.
  • Arginine sometimes reactivates latent herpes virus infections. Those with ocular or brain herpes should avoid it. Persons with herpes benefit from lysine which competes with arginine in amino acid metabolism. If you have herpes and use arginine at all, use lysine at a separate time of day on an empty stomach to avoid lysine depletion and herpes exacerbations.
  • Arginine should be used with care in those with psychosis because they may experience a worsening of symptoms.
  • Arginine should always be taken with antioxidants.

L Arginine is an essential amino acid. It causes the secretion of growth hormone. In fact, a 15 to 30 gram intravenous infusion of arginine is used as a standard endocrinological test to provoke the pituitary into releasing growth-hormone.

L Arginine Stimulate HGH

A study at the University of Turin, Italy, showed that even though people in their seventies had lower response than either children or young adults to arginine, the nutrient still boosted their blood levels of HGH to triple the average for their age group. Arginine appears to stimulate HGH by blocking the secretion of the growth-hormone inhibitor somatostatin. It also greatly enhances the effect of growth hormone-releasing hormone when they are given together.

Positive claims for arginine include increasing fat burning and building muscle tissue probably through the stimulation of growth-hormone, increasing the weight and activity of the thymus gland, boosting immunity, fighting cancer, promoting healing of bums and other wounds, protecting the liver and detoxifying harmful substances, and enhancing male fertility. It also restores sexual function in impotent men. In a 1994 study by Drs. A.W. Zorgniotti and E.E Lizza of the department of urology/surgery at New York University School of Medicine, six of fifteen men who took 2,800 milligrams of arginine a day for two weeks had renewed sexual performance, specifically improved erection, yet none of the men on the placebo did. The researchers believe that arginine worked because it is a precursor of nitric oxide, which plays a key role in initiating and maintaining an erection.