Arginine Alpha-Ketoglutarate provides far
superior uptake and retention as compared with regular L-Arginine. The unique
combination of ingredients in this product make it the strongest nitric oxide
supplement on the market.
vessels, normalize blood pressure, replicates the activity of nitroglycerine,
and is needed to produce nitric oxide
L-arginine, along with a properly planned
exercise program, assists in amending abnormalities occurring in blood vessels.
Individuals with congestive heart failure often have blood vessels that fail to
dilate in response to certain drugs, a sign that the inner blood vessel wall, or
endothelium, is compromised.
A study reported in the American College of
Cardiology concluded that treatment with L-arginine produced a fourfold increase
in blood vessel dilation from 2.2-8.8% (Hambrecht et al. 2000). Regular forearm
exercises increased the dilation response by the same amount, but the
combination of L-arginine and exercise training resulted in an improvement from
2.9-12%. Doses of 5.6-12.6 grams of arginine increased blood flow to the
extremities 29%; the distance walked on a treadmill in 6 minutes increased 8%
(Rector et al. 1996).
Much of L-arginine's effectiveness comes by way
of increasing nitric oxide, a blood vessel dilator and clot buster produced in
endothelial cells by the enzyme nitric oxide synthase (Brunini et al. 2002).
Nitric oxide counteracts the vasoconstriction and platelet-aggregating effects
of the stress hormone adrenaline (epinephrine) and assists in maintaining
vascular elasticity. Nitric oxide (the endothelial relaxing factor) is needed
for expansion and contraction of the arterial system (Rohdewald 1999). L-arginine
increases nitric oxide, but hypertension, hyperhomocysteinemia, diabetes, and
smoking decrease it.
Because of arginine's vasodilating properties, it
is frequently used as a treatment for angina pain and hypertension. Researchers
at the University of Southern California ( Los Angeles ) speculate that a defect
in nitric oxide production may be a possible mechanism of hypertensive disease (Campese
et al. 1997). Some cardiologists, in fact, recommend L-arginine over
nitroglycerine, since the two substances appear to replicate a similar vascular
function: the ability to relax smooth muscles and dilate blood vessels.
L Arginine & Nitric Oxide
Nitric oxide is a
soluble free gas naturally produced in the body (from the amino acid arginine)
by endothelial cells, macrophages, and specific neurons in the brain. Nitric
oxide plays several key roles in the body, including:
Nitric oxide relaxes vascular smooth muscle, which causes
Nitric oxide reduces platelet aggreg r ation and
Nitric oxide produced by macrophages is cytotoxic to
certain microbes and tumor cells.
Nitric oxide has been identified as having a key
role in blood pressure regulation. Nitric oxide lowers blood pressure by
stimulating the release of calcium from vascular smooth muscle cells, thereby
causing the blood vessels to relax and dilate. There is now evidence that nitric
oxide deficiency can cause hypertension and may also be involved in the
pathogenesis of atherosclerosis. Nitric oxide donors (such as nitroglycerine and
arginine) lower blood pressure and increase cerebral blood flow in patients with
acute ischemic stroke.
L Arginine Modulating Nitric
The best naturally occurring source of nitric
oxide is the amino acid arginine. A study examined the use of L-arginine to
prevent experimental ischemic stroke in rats. L-arginine was administered at the
time of ischemia and at 6 and 24 hours later. The areas of neuronal necrosis
were reduced by 99%, 96%, and 89%, respectively. The study also examined L-arginine
in combination with a calcium antagonist (TMB-8) and found that the combination
of TMB-8 and L-arginine is more effective in treating ischemic stroke by
simultaneously reducing calcium-activated proteolysis and improving cerebral
blood flow than using TMB-8 or L-arginine alone (Hong et al. 2000).
However, to avoid the potentially harmful
free-radical damage that can result from excessive nitric oxide, one of the
vitamin E fractions, gamma tocopherol, has been found to function as the best
antioxidant for nitric oxide. Therefore, for best stroke, heart disease, and
hypertension protection, consider arginine, 2700 mg 3 times per a day with
plenty of B complex as cofactors and 400 IU of gamma tocopherol for optimal
Precautions when supplementing
Diabetics and borderline diabetics should use arginine
with care because it may worsen diabetes.
Children, teenagers, and pregnant or lactating women
should not use arginine (or growth hormone stimulators) except under the
care of a knowledgeable physician.
Arginine sometimes reactivates latent herpes virus
infections. Those with ocular or brain herpes should avoid it. Persons with
herpes benefit from lysine which competes with arginine in amino acid
metabolism. If you have herpes and use arginine at all, use lysine at a
separate time of day on an empty stomach to avoid lysine depletion and
Arginine should be used with care in those with psychosis
because they may experience a worsening of symptoms.
Arginine should always be taken with antioxidants.
L Arginine is an essential amino acid. It causes
the secretion of growth hormone. In fact, a 15 to 30 gram intravenous infusion
of arginine is used as a standard endocrinological test to provoke the pituitary
into releasing growth-hormone.
L Arginine Stimulate HGH
A study at the University of Turin, Italy, showed
that even though people in their seventies had lower response than either
children or young adults to arginine, the nutrient still boosted their blood
levels of HGH to triple the average for their age group. Arginine appears to
stimulate HGH by blocking the secretion of the growth-hormone inhibitor
somatostatin. It also greatly enhances the effect of growth hormone-releasing
hormone when they are given together.
Positive claims for arginine include increasing
fat burning and building muscle tissue probably through the stimulation of
growth-hormone, increasing the weight and activity of the thymus gland, boosting
immunity, fighting cancer, promoting healing of bums and other wounds,
protecting the liver and detoxifying harmful substances, and enhancing male
fertility. It also restores sexual function in impotent men. In a 1994 study by
Drs. A.W. Zorgniotti and E.E Lizza of the department of urology/surgery at New
York University School of Medicine, six of fifteen men who took 2,800 milligrams
of arginine a day for two weeks had renewed sexual performance, specifically
improved erection, yet none of the men on the placebo did. The researchers
believe that arginine worked because it is a precursor of nitric oxide, which
plays a key role in initiating and maintaining an erection.