CitricomaTM is a proprietary blend of polymethoxylated flavones (PMFs) and Eurycoma Longifolia that may help maintain healthy cholesterol level, promote anabolic state during weight loss program that is essential for healthy weight management.

There are many diet programs in the market. However, most weight loss programs have high drop out rate because of stress during weight loss programs can put the body into the catabolic state, in which the body can experience muscle loss, fatigue, reduced metabolic rate, low energy levels, binge eating, and eventual weight gain in the form of fat.

Metabolic Challenges

Obesity, diabetes, and metabolic syndrome (“Syndrome X” – encompassing insulin resistance, type 2 diabetes, dyslipidemia, hypertension, and abdominal obesity) are reaching epidemic proportions in the United States and around the world. Excess glucocorticoids such as cortisol (a primary stress hormone) have been theorized to contribute to visceral (abdominal) obesity and diabetes.  Our body undergoes major changes past 30 years of age.  Science has shown a clear link between metabolic syndrome and adipose tissue.  While the formation of adipose tissue results for a variety of reasons, in many adults this occurs due to changes in hormone balance.   Specifically, there is a decrease in Androgen hormones (DHEA, Testosterone, etc.) and an increase in Sex Hormone Binding Globulin.  While these types of hormones are primarily associated with sexuality, they act in concert with other hormones and control a wide array of metabolic functions. 

Its important to understand that adipose formation is not bad because adipose tissue is actually a part of the endocrine system, creating a number of hormones to help the body support endocrine deficiencies.  However, it can also over form and cause a host of health imbalances.

Anabolic vs Catabolic State

One way of categorizing metabolic processes, whether at the cellular, organ or organism level is as anabolic or catabolic. Catabolism is the part of metabolism that breaks down molecules into smaller units to generate energy and simultaneously takes measures to conserve energy. Stress, such as during weight loss program, can put the body into the catabolic state, in which the body can experience muscle loss, reduced metabolic rate with a corresponding reduced calorie expenditure and lower perceived energy levels, and weight gain in the form of fat. One aspect of the catabolic state is that it can be characterized as having high cortisol (a catabolic stress hormone) levels and low testosterone (an anabolic hormone) levels.

Conversely, in the anabolic state the body experiences muscle maintenance or growth, normal metabolic rates, and weight loss in the form of fat. The anabolic state can be characterized by relatively low cortisol levels and high testosterone levels.

11(beta)-HSD1 enzyme

11(beta)-HSD1 is an enzyme that plays an important role in the cellular interconversion of glucorticoids between the active (cortisol) and inactive (cortisone) forms. Thus, 11(beta)-HSD1 is responsible for the modulation of cellular cortisol exposure and as such plays an important role in a number of health imbalances associated with excess glucocorticoid.  11(beta)-HSD1 is present in the liver and the adipose tissue. 11(beta)-HSD1 amplifies local glucocorticoid concentrations in these target tissues, even when circulating cortisol levels are low. In obese subjects, adipose levels of 11(beta)-HSD1 levels are markedly increased and animal models of elevated 11(beta)-HSD1 activity demonstrate visceral obesity, insulin resistance, diabetes, and dyslipidemia. Inhibition of 11(beta)-HSD1 in animals (pharmacologic and genetic) and humans (pharmacologic) results in enhanced insulin sensitivity.

The 11(beta)-HSD1 enzyme modulates tissue-specific glucocorticoid concentrations by generating active cortisol. Previous research has shown both liver 11(beta)-HSD1 and adipose tissue 11(beta)-HSD1 to be associated with hyperinsulinemia (diabetes) and visceral adiposity (abdominal obesity), respectively.   Rodent models of diabetes and obesity display elevated 11(beta)-HSD1 expression and transgenic mice with elevated 11(beta)-HSD1 develop visceral obesity, diabetes, and elevated cholesterol levels. Transgenic “knockout” mice (which lack 11(beta)-HSD1) are resistant to diabetes and obesity, even when fed a high-calorie diet. Obese and diabetic human subjects have been shown to exhibit elevated 11(beta)-HSD1 levels and activity – and inhibition of 11(beta)-HSD1 activity with selective or non-selective agents has been shown to improve insulin sensitivity.

What is Citricoma?

Citricoma TM is an innovative nutraceutical ingredient for healthy weight management. Citricoma TM promotes healthy weight loss by maintaining healthy androgen and cortisol level, healthy blood glucose level, healthy cholesterol levels, and helps dieters maintain high energy levels while reducing the body’s shift to a catabolic state during weight loss program.

The citrus PMFs ( Polymethoxylated Flavones) found in Citricoma TM inhibits the 11(beta)-HSD1 enzymes, thereby reducing cortisol concentrations in adipose tissue, promoting healthy blood sugar control, healthy cholesterol, and healthy weight loss. Eurycoma Longifolia in Citricoma TM help to promote an anabolic state by maintaining low normal cortisol level and high normal androgen levels during the stress of a weight loss program. This hormonal control additionally provides energy by increasing ATP production while simultaneously aiding healthy weight management by increasing the body’s basal metabolism rate.

Citricoma™ diet program

Citricoma TM diet program is easy to follow. Eat three meals each day (400-600 kcal/meal) according to the diet chart below, with 2 small snacks between each meals.

Exercise (walk, jog, or yoga) for at least 30 minutes 3 times a week. Take 200mg of Citricoma TM supplement every morning for that extra energy boost and healthy weight loss.

Citrus PMFs

Citrus peel extract includes Polymethoxylated Flavones (PMFs), particularly tangeretin, sinensetin, and nobilitin, which are known to have health benefits in maintaining healthy cholesterol level and promoting cardiovascular health. PMFs represent a class of “super flavonoids” extracted from citrus peels that exhibit approximately 3-fold potency in their ability to reduce cholesterol levels as compared to other citrus flavonoids.  Citrus PMF inhibits the 11(beta)-HSD1 enzymes, thereby reducing systemic and local cortisol concentrations (liver and adipose tissue), promoting healthy blood sugar control and healthy weight loss.

Eurycoma Longifolia

Eurycoma (Eurycoma Longifolia, also known as Tongkat ali and Malaysian ginseng) specifically the Eurypeptides, have known to increase energy levels and enhance libido in older men.  Eurypeptides are long chains of amino acids helps enhance weight loss and maintain high energy levels by maintaining normal levels of cortisol and testosterone during weight loss (anabolic state). More particularly, Eurycoma is used to help maintain normal (low) cortisol and normal (high) testosterone levels during the stress of weight loss. This hormonal control provides energy to a person in a weight loss phase while simultaneously helping them lose weight. As a result, effective doses of Eurycoma help prevent the body from seeking to gain weight by storing fat and increasing appetite, thereby help stop the “yo-yo” diet effect where a dieter’s initial weight loss of a few pounds sends the body into a catabolic state, leading to binge eating and fat storage. In addition, it is believed that inhibiting or reducing the cortisol spike associated with weight loss can make it easier for a person to control their appetite. Similarly, it is believed that controlling the cortisol and testosterone levels helps prevent the body from increasing fat storage and increases a person’s baseline energy.

Maintain Anabolic State

By reducing the cortisol spike and maintain high normal testosterone level, Citricoma TM helps dieters to better control their appetite by preventing the body’s shift into a catabolic state during weight loss program, which usually involves binge eating and storage of excess calories as fat.

Maintains Healthy Androgen Levels & Reduce Cortisol

Science has shown a link between metabolic syndrome, adipose tissue, and changes in hormone balance, such as a decrease in Androgen hormones (DHEA, Testosterone, etc.), and an increase in Sex Hormone Binding Globulin (SHBG) and cortisol. Citricoma TM helps healthy weight management by maintaining high normal androgen levels, decreasing SHBG levels, and normalizing the release of cortisol.

Improve Energy and Reduce Fatigue By maintaining a high normal testosterone level, Citricoma TM helps to increase energy level by increasing ATP production, increase metabolism rate, and reducing fatigue.

Inhibits 11(beta)-HSD1 enzyme 11(beta)-HSD1 is an enzyme that is responsible for converting cortisol into cortisone, increasing cortisol concentrations in the adipose tissue in overweight individuals, leading to increased abdominal fat, insulin resistance, and elevated cholesterol levels. Citricoma TM inhibits 11(beta)-HSD1 enzymes, thereby helping to maintain normal cortisol level in the adipose tissue, healthy insulin sensitivity, and healthy cholesterol levels.

Citricoma TM Human Clinical

50 moderately overweight men and women were recruited to participate in a 6-week program of stress management, nutrition intervention and exercise. 40 were given 200mg of Citricoma TM and 10 were given placebo . Results showed Citricoma TM supplementation together with overall lifestyle program significantly reduced body weight (BW) and body fat (BF), improve overall mood, reduced stress, reduced depression, reduced fatigue and improve overall vitality compared to placebo group. Citricoma TM helps to promote anabolic state by maintaining high normal level of testosterone (+14%) and low normal level of cortisol (-15%). Supplementation with Citricoma TM additionally help to reduce total cholesterol by 16% and LDL by 20%, a result not seen in the placebo group.

Research

BACKGROUND

According to articles published in the nutrition journal, the author strongly suggests that stress/cortisol exposure is associated with increased appetite, weight gain, and specifically with increased abdominal adiposity.  Weight gain is significant and weight loss difficult during the 6-week holiday period as anecdotal reports and subjective assessment of holiday weight gain may be high.  High cortisol secretion is associated with abdominal fat and abdominal fat is most highly associated with illness and death from cardiovascular disease, diabetes, and metabolic syndrome, including hypertension, hyperlipidemia, hyperinsulinemia, & insulin resistance. 

  Women with high cortisol response (compared to low responders) usually consumed more calories, ate significantly more sweet foods, and had more negative moods.  Most weight loss programs require Dietary Restraint, where we consciously trying to limit food intake to achieve or maintain a desired body weight.  However, High dietary restraint is associated with high urinary cortisol excretion indicating stress associated with following the diet program.
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Effect of LJ100 on Anabolic Balance During Endurance Exercise
Talbott S, Talbott J, Negrete J, Jones M, Nichols M, and Roza J.
SupplementWatch, Inc. Draper, UT & Source One Global Partners, Chicago , IL
Published:  Journal of International Society of Sport Medicine 3 (1): S32  2006

Eurycoma longifolia, commonly known as “Tongkat Ali” or “Longjack,” is often touted as a testosterone “booster” and marketed to athletes as a training aid and performance enhancer. Rodent studies have shown oral delivery of Eurycoma extract to improve sexual performance and increase serum testosterone levels. Open-label human trials have suggested that Eurycoma extract may help prevent age-associated androgen deficiency, improve sexual function, and increase psychological parameters such as mood, energy, and sense of well-being. The purpose of this study was to determine the effects of Eurycoma longifolia on testosterone and cortisol levels during intense endurance exercise.
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Background: Previous studies have shown that weight loss induced only by dietary restriction results in undesirable losses in fat-free mass, elevations in cortisol, and reduction in testosterone levels. Combining dietary restriction with aerobic or strength training exercise, is known to enhance fat loss and attenuate the loss of muscle mass to varying degrees.
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Other Ingredients :

Gelatin capsules.

Suggested Use :

Take 2 capsules daily. Do not exceed four capsules daily.  It is recommended that this product be taken regularly to experience continuous benefits.

 

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